Formulation Development and in vivo Evaluation of Nevirapine Solid Dispersions by Solvent Evaporation Technique
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منابع مشابه
A Novel Formulation of Orlistat Solid Dispersions Using Solvent Evaporation Technique
Solubility is an important physicochemical factor affecting absorption of drug and there by its therapeutic effect. About 40% of newly discovered drugs are lipophilic and failed to reach market due to their poor water solubility. Solid dispersions proved to have tremendous potential for improving drug solubility. Orlistat is a poor water soluble substance possessing anti-obesity property; in th...
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PURPOSE The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties. METHODS Polyvinylpyrrolidone (PVP), Poloxamer 188 and Cremophore RH40 were used to prepare the solid dispersions of sirolimus. In vitro dissolution study using USP type I apparatus, were performed in distilled ...
متن کاملFormulation & Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions
Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
متن کاملDevelopment and in-vivo assessment of the bioavailability of oridonin solid dispersions by the gas anti-solvent technique.
We developed solid dispersions, using the gas anti-solvent technique (GAS), to improve the oral bioavailability of the poorly water-soluble active component oridonin. The solubility of oridonin in supercritical carbon dioxide was measured under various pressures and temperatures. To prepare oridonin solid dispersions using the GAS technique, ethanol was used as the solvent, CO(2) was used as th...
متن کاملFormulation and Evaluation of Sustained Release Microspheres of Acetazolamide by Solvent Evaporation Technique
ISSN:0975-1459 Sustained release microcapsules of acetazolamide, a short half life carbonic anhydrase inhibitor, was developed to reduce the frequency of drug administration, ease of dose adjustment and improve patient compliance. In this study, sustained release microcapsules of acetazolamide was prepared by solvent evaporation techniques using Eudragit RL/RS as polymer and particle size, enca...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Sciences and Drug Research
سال: 2018
ISSN: 0975-248X
DOI: 10.25004/ijpsdr.2018.100304